The Leukemia & Lymphoma Society (LLS) is out to prove the benefit of everyday kindness, on the third annual National Random Acts of Light Day, set for June 13. In conjunction with LLS’s Light The Night campaign, Random Acts of Light aims to create awareness and educate the public about the critical need to fund research to find cures for blood cancer patients, and ensure they have access to lifesaving treatments. In celebration of bringing light to more than 50 cancer patients since the campaign launched in 2016, LLS is highlighting some remarkable young survivors who were featured in Random Acts of Light campaign in 2019.
Athena Receives a Chocolate Lover’s Dream
Eight-year-old Athena, an acute lymphoblastic leukemia (ALL) survivor, is a huge chocolate lover. In fact, chocolate helped her cope with her treatment. When she was surprised with a day to be a “kid in a candy shop” at Aigner Chocolates in Forest Hills, NY, she was living a chocolate lover’s dream. Athena received a tour of the chocolate shop, including unlimited taste tests! She even went home with a two-foot bunny – more chocolate than she could carry!
Mikah Becomes a NFL Player for a Day
Last year, five-year-old Mikah was diagnosed with B-cell acute lymphoblastic leukemia, but chemotherapy didn’t stop him from becoming a “Los Angeles Charger for a day” when he was presented with a Random Act of Light from LLS and the Chargers. His special surprise included hanging out with Chargers center Scott Quessenberry, a personal tour of Hoag Performance Center, a personalized nameplate in the locker room and more.
Daylin Receives a Surprise of a Lifetime: A Trip to Disney
When 13-year-old Daylin of Lake Wales, FL, was diagnosed with acute myeloid leukemia (AML) in May 2018, he was given a 10 percent chance of survival. A bone marrow transplant from his mom ultimately saved his life, and today, Daylin is in remission. To brighten his spirits, LLS surprised Daylin with three all-inclusive tickets to Busch Gardens Tampa! In addition, the aspiring football player received a jersey signed by his idol, NFL wide receiver, Odell Beckham Jr.
Want to get involved?
Despite the many advances in cancer treatments and survival rates, many patients are still living with cancer and experiencing the darkness that can come with it. If you want to join the movement and bring light to someone you know who has been touched with cancer, here are some ways you can get involved:
Post about National Random Acts of Light Day on June 13 and tag #RandomActsofLight across your social channels
Create a special experience for someone touched with cancer in your community – this can be however big or small. Some ways you can help:
Surprise a family in the hospital with a meal or gift certificate
Give a patient or survivor free tickets to a game for their favorite team
“What is your goal as a doctor?” Atul Gawande, M.D., a surgeon, writer, professor, and staff writer for The New Yorker, asked the audience of thousands of clinicians, researchers and other healthcare professionals as the guest speaker at the opening session of the 2019 ASCO (American Society of Clinical Oncology) Annual Meeting in Chicago. Gawande wrote the book, “Being Mortal,” about palliative care, and in his talk on Saturday he pondered that doctors’ ideas about best care are not always aligned with patients’ priorities. Survival at any cost, including poor quality of life, may not always be the endgame for a patient. Maybe a doctor’s goal for a terminally ill patient should be to give them “their best possible day today regardless of what the consequence is tomorrow,” Gawande suggested.
As this #ASCO19 winds down, I sifted through the thousands of presentations to reflect on just a few highlights:
One study presented this weekend shows a connection between expansion of Medicaid under the Affordable Care Act (ACA) and a reduction in racial disparities in accessing timely cancer care. Prior to the ACA going into effect, African Americans with advanced cancer were 4.8 percent less likely to receive timely treatment compared with white patients. These racial disparities all but disappeared in states where expansions were implemented. LLS is committed to taking on disparities as well. We have a program called Myeloma Link focused on bringing information about myeloma to African American communities through churches and community centers, as African Americans are twice as likely white Americans to develop myeloma, but less likely to access care and treatment.
Novel Targets in Myeloma
As immunotherapy becomes a mainstay of cancer treatment, innovative approaches to engage the body’s immune system are showing promise in treating patients with multiple myeloma (MM). An antibody treatment called daratumumab (Darzalex (R) is approved for relapsed MM patients, and continues to be tested in various triple, even quadruple combinations with encouraging results, possibly paving the way as a new first-line therapy. Needless to say, combining four treatments can pose significant cost barriers. Daratumumab targets a protein called CD38, but another protein called B-cell maturation antigen, or BCMA, also found on the surface of myeloma cells, is another compelling experimental target.
One experimental approach, chimeric antigen receptor (CAR) T-cell therapy, programs the patient’s own T cells to home in on the BCMA protein on the myeloma cells. These CAR-Ts have shown good initial response rates in clinical trials but to date the CAR-T cells don’t last and most of the myeloma patients eventually relapse.
Another type of immunotherapy competing with CAR-T is called a bispecific T-cell engager (BiTE). The BiTE is engineered with two different antibodies, one that links to the BCMA on the surface of the myeloma cell and the other that links to the cancer killing T cells, forming a bridge that delivers the T cells to the tumor. A study presented at the ASCO meeting of AMG 420, a BiTE being developed by Amgen, showed responses in 13 or 42 patients in a Phase 1 trial. There is, however, serious concern about toxicity with this drug, with some of the patients requiring hospitalization. For both the BCMA targeting CAR-T and the BiTE, the durability of response remains a question. Developing CAR-T cells is more onerous as they have to be tailor-made for each patient, while BiTEs can be manufactured “off the shelf” as a uniform product for all patients.
More Chemo-Free Combos for CLL
Chemotherapy, which kills cancer cells by attacking the DNA of the cells, can be effective, even curative, but can also causes harm to healthy cells. Chemo has been the standard of care for many cancers for decades, including chronic lymphocytic leukemia (CLL). But more chemo-free combination therapies that target bad-acting genes while sparing the healthy cells, are pushing chemo regimens aside.
Two powerhouse breakthrough therapies, ibrutinib (Imbruvia (R) and venetoclax (Venclexta (R), both oral medications that target different genetic mutations, are each approved individually for CLL. LLS has supported research over an extended period of time to advance both of these therapies. Now a study published the Wednesday before the ASCO meeting in The New England Journal of Medicine and discussed during the meeting, shows strong response rates when the two drugs are combined, and could become the new standard of care, particularly for older adults with high-risk CLL.
While The Leukemia & Lymphoma Society is, of course, focused on cancers of the blood, results of a study in pancreatic cancer brings home the message that precision medicine, matching patients to medicines based on their genetic profile and other factors, is becoming more than just a buzz word. A medicine, olaparib (Lynparza ®) which is FDA-approved for breast and ovarian cancer patients who test positive for the BRCA gene, is showing that it might also work for patients with pancreatic cancer who have the same mutation. For patients in that subgroup, this is hopeful news for one of the most deadly and impenetrable cancers. A study of the drug showed that patients went twice as long without their tumors growing on this drug as compared to patients receiving a placebo. The patients in both groups were first treated with standard chemotherapy.
Of course, LLS has been leading a groundbreaking precision medicine trial of our own to conquer one of the most deadly blood cancers, acute myeloid leukemia. The Beat AML Master Clinical Trial is more than two-and-a-half years under way, using sophisticated genomic technology to test multiple targeted drugs at multiple clinical sites. To date, more than 550 patients have been screened in the trial and our first data was presented in December. Now we're looking to expand on this successful model to pediatric acute leukemia and other adults with other cancers over the coming year. Stay tuned…
As The Leukemia & Lymphoma Society (LLS) embarks on a quest to disrupt the status quo in treatment and care for children with cancer, I was interested to learn the latest in children’s oncology while here at The 2019 ASCO (American Society of Clinical Oncology) annual meeting. More than 40,000 cancer scientists, clinicians, advocates, biopharmaceutical company reps and others from around the world are in Chicago to gauge where we are in cancer research and where we still need to go.
LLS seeks to bring about a wholesale shift in the standard of care for pediatric patients. Too many children are still dying from acute leukemia, and for those who do survive, the toxic chemotherapies leave many with lifelong health challenges. We are determined to advance safer more effective treatments that precisely target cancer without harming the rest of the child’s body. Through The LLS Children’s Initiative we are doubling our investment pediatric cancer research, and expanding services like back to school programs for children, education programs for pediatric physicians and financial assistance for families of children with cancer. And we are convening an unprecedented collaboration with a goal of launching a global precision medicine clinical trial for children with acute leukemia next year. We’re calling the trial LLS PedAL (for pediatric acute leukemia).
With all this in mind, I set out this weekend to learn what I could about the state of pediatric cancer treatment.
A Friday session presented results of several clinical trials investigating new treatments for children with cancers, including sarcoma, neuroblastoma and acute myeloid leukemia (AML).
While we have seen progress in new therapies for adults with AML – seven in all approved in 2017 and 2018 - progress for children with AML has lagged. Children are not mini-adults and they need fundamentally different strategies.
Two of the studies presented Friday offered signs of hope.
Todd Michael Cooper, M.D., of Seattle Children’s Hospital described a study testing the drug CPX-351 (Vyxeos®) in children aged 1-21 with relapsed AML. LLS supported the early development of this drug through our Therapy Acceleration Program (TAP). Vyxeos is a reformulation of two standard chemotherapy drugs encased in a tiny liquid bubble, optimizing the ratio and delivery of the medicine. It was approved for adults with secondary AML in 2017, marking the first new therapy for AML in decades.
Cooper said the study’s goal is to get the children into remission long enough to bridge them to a potentially curative stem cell transplant. The children were treated with a regimen of CPX-351 followed by a combination of standard chemotherapies. Of the 38 patients enrolled, 68 percent achieved a complete remission, and 83 percent of t hose patients were able to have a successful stem cell transplant. Cooper said the results warrant further study in a Phase 3 trial. Cooper is also part of a task force working with our Chief Medical Officer Gwen Nichols, M.D., to develop the LLS PedAL trial.
Jeffrey E. Rubnitz, M.D., of St. Jude Children’s Hospital, followed with a presentation on another breakthrough therapy recently approved for adult AML patients. LLS long-supported the early research of this therapy, venetoclax (Venclexta ®), first leading to its approval in chronic lymphocytic leukemia, and last year for AML.
Rubnitz showed in an early study that venetoclax was safe and well tolerated by children, and 75% of the children achieved a complete remission. He noted two children in particular, a seven-year-old and 11-year-old boys, respectively, both of whom were highly resistant to treatment but achieved remission with no evidence of disease with this regimen and went on to have stem cell transplants.
Michael Zwaan, M.D., of Erasmus MC-Sophia Children’s Hospital and Princess Maxima Center of Pediatric Oncolgy Utrecht, in Rotterdam, The Netherlands, moderated the session. In conclusion he posed the question: Can we move beyond cytarabine? (the standard chemotherapy used for decades to treat children with leukemia. His answer “Yes we can!”
Dr. Zwaan said his institution and others in Europe are eager to participate in LLS’s PedAL because well-designed trials in relapsed AML are sorely needed.
CAR-T for Glioblastoma in Children?
The revolutionary chimeric antigen receptor (CAR) T-cell therapy is a procedure first pioneered in the blood cancers that trains a patient’s own T cells to find and kill cancer cells. It appears to be curing hundreds of leukemia and lymphoma patients who had relapsed multiple times and had run out of options. Since it made history gaining approval in 2017 for children and young adults with acute lymphoblastic leukemia, and adults with relapsed lymphoma, scientists have been trying to get this therapy work for patients with other cancers like myeloma and AML, as well as for solid tumors. To date, they are still confounded by the challenges of making it work for these other patients.
Staying with the theme of pediatric cancer treatment, I attended a session on Saturday afternoon focused on clinical trials testing CAR-T in children with glioblastoma, a tumor of the brain. Nabil Ahmed, M.D., of Baylor College of Medicine, discussed the results of several trials. To date, despite glimmers of hope, success in treating glioblastoma patients with CAR-T has been fleeting. The obstacles include:
Too many different types of cancer cells within a single tumor, making it hard to find the right combination of treatments. Multi-CAR-Ts (“carpools) may need to be developed, Ahmed said.
CAR-T cells have been described as a living drug because they continue to multiply and attach the cancer once they are infused back into the patient, but in clinical trials for solid cancers, the CAR-T cells do not persist for more than several days, weeks or months.
The antigens - the specific molecules that the CAR T-cells are designed to attack - are disappearing for some reason.
While the progress has been halting, Ahmed said there is reason for optimism as researchers are determined to devise strategies and will ultimately succeed in overcoming these challenges.