What is TAP?
TAP is a strategic venture philanthropy funding initiative to accelerate high-risk, innovative blood cancer therapeutics and change the standard of care in leukemia, lymphoma, and multiple myeloma.
Since its establishment in 2007, TAP has invested more than $125 million in over 70 projects.
"Funding from leaders like LLS TAP helps fuel the progress of our clinical development program, bringing next-generation treatments that much closer to patients. We're particularly excited to be working with LLS TAP because it gives us access to their deep knowledge of blood cancer and their network of patients and drug development experts."
- Rachel Haurwitz, Ph.D., Co-Founder, President and Chief Executive Officer of Caribou Biosciences
Since 2017, four TAP-supported therapies have been approved by the U.S. Food and Drug Administration (FDA) or included in the National Comprehensive Cancer Network (NCCN) Guidelines:
CPX-351 (Vyxeos®), first approved treatment (an innovative reformulation of two chemotherapies) for patients with certain types of high-risk acute myeloid leukemia (AML) - approved on August 3 2017 with clinical data published in Journal of Clinical Oncology
Axicabtagene ciloleucel (Yescarta®), first CAR T-cell immunotherapy approved for patients with non-Hodgkin lymphoma (NHL) and transformed follicular lymphoma (tFL) - approved on October 18 2017 with clinical data published in Lancet Oncology
Tagraxofusp-erzs (Elzonris®), first approved therapy for children and adults with blastic plasmacytoid dendritic cell neoplasm (BPDCN) - approved on December 21 2018 with clinical data published in New England Journal of Medicine
Duvelisib (Copiktra®), first dual inhibitor of PI3K-delta and gamma pathways to be included in NCCN Guidelines as a designated option for patients with all subtypes of peripheral T-cell lymphoma (PTCL) - included on December 22 2021 with clinical data presented during the 2021 ASH Meeting
Currently, there are over 20 active clinical studies with TAP-supported therapies, including 6 registration-enabling clinical studies (4 in blood cancer & 2 beyond blood cancer).
“Through our partnership with LLS, we have access to their deep knowledge and expertise in hematologic oncology, and to their extensive physician and patient network. By working together, we can accelerate development of our lead product IO-202, a myeloid checkpoint inhibitor, for AML and CMML and help patients who need new treatment options.”
- Charlene Liao, PhD, Co-Founder, President, and Chief Executive Officer of Immune-Onc Therapeutics
View archived TAP webcasts and programs
- Expanding the Possible with Next-Generation Cell Therapies (Archived January 2022)
- Value Creation for Companies: Dollars & Beyond (Archived December 2020)
- LLS Research Now: LLS’s Venture Philanthropy Model for Accelerating Promising Therapies (Archived October 2020)
- LLS Business Networking Reception ASH 2019 (Archived December 2019)
How can TAP benefit your company?
Hear what the SVP of Corporate & Business Development of Stemline Therapeutics has to say about TAP and the value created for his company beyond the funding amount. LLS TAP partnered with Stemline in 2013 to support key clinical studies for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN).