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Monica

As a First Connection® volunteer with The Leukemia & Lymphoma Society (LLS) for almost two years, I have had the opportunity to connect with patients and survivors to share their stories and experiences while battling this deadly illness. Every day I come across so many touching and courageous stories that inspire me to do more and more to support this cause.

Targeting kinase-dependent dysregulation of transcription factor control in acute myeloid leukemia

Defining mechanisms of dysregulated gene control are central to understanding cancer and the development of effective therapies. Our research is focused on the mechanisms of gene control dysregulation in acute myeloid leukemia (AML), a refractory form of blood cancer that affects both children and adults. Using new methods for manipulating proteins, we are defining essential mechanisms by which AML cells enable cancer-causing gene expression. This work also allowed us to develop new drugs to specifically block this in cancer, but not healthy cells.

Synergistic targeting of metabolic and epigenetic vulnerabilities in leukemia stem cells

Our lab is focused on identifying unique features that distinguishes acute myeloid leukemia (AML) stem cells from normal blood-forming stem cells. The cells that make more AML cells than others are called AML stem cells, and these cells need to be eradicated to achieve deep therapeutic responses. We believe targeting metabolism may achieve this goal and found strategies to target AML stem cell metabolism without harming normal stem cells. We hope that our study will lead to improved therapies against AML targeting metabolism to achieve deep remission with little toxicity.

Lorna

I was diagnosed with Stage 4 NH large B-Cell primary hepatic lymphoma in April, 2013. I was told by my doctor that this was a very rare form of lymphoma with less than 200 cases in the US. I had surgery to remove 90% of the right lobe of my liver as the tumor was very large at 16cm (initially I was diagnosed with liver cancer until they removed the tumor and the pathology revealed that it was NH lymphoma).

George

My awareness of The Leukemia & Lymphoma Society (LLS) began years ago when a close family member was diagnosed with leukemia. In the wake of such devastating news, I felt compelled to lend a hand.  I am honored to join the LLS family in their fight to cure blood cancers.

Janice

At the age of 56, I was diagnosed with T-cell B-cell lymphoma. The diagnosis was made in May 2021. Although diagnosed at the Washington D.C. Veterans Hospital, I was referred to the National Institute of Health (NIH) in Bethesda, Maryland. I was blessed to be placed in a clinical trial as the first patient with this form of lymphoma. 

Doug

In July 2014, my defibrillator fired while I was at a diner. Upon testing at the hospital I found out I have acute promyelocytic leukemia (APL). Much to my surprise, it was discovered by a simple blood test.

Keith

When the doctor calls you and says, "I need to speak to you as soon as possible," you know the news can't be good. I was diagnosed with a rare and aggressive form of leukemia, bastic plasmacytoid dendritic cell neoplasm (BPDCN). Most doctors have never even heard of it.

Leanne

In November 2023, on my 40th birthday, I had a biopsy on my neck for a swollen lymph node. We originally thought it was thyroid issues, but several scans and biopsies later led me to Sylvester Cancer Center at the University of Miami. A week later, I was diagnosed with diffused large B-cell lymphoma CD30+ (DLBCL), which I like to say is Hodgkin and non-Hodgkin lymphoma in one big bang, an aggressive rare form of cancer that required a specialized treatment with revolutionary drugs.

Nikolette

I was truly honored to be a recipient of The Leukemia & Lymphoma Society (LLS) Scholarship for Blood Cancer Survivors. After fighting two different types of cancer, both forms of lymphoma and leukemia, I was unsure what my collegiate education would look like. I had to medically withdraw from my freshman year of college at Penn State University in the fall of 2018 when I received my second diagnosis. My family and I were completely devastated, but I was able to successfully undergo a bone marrow transplant and have been showing no evidence of disease (NED) for 3½ years now!

Anita

I was diagnosed with lymphoma in June, and on December 14, received the news I was in remission. I had primary mediastinal B-cell lymphoma (PMBL) to be exact. It is a very aggressive form of cancer, and within two weeks of being diagnosed, I had started chemotherapy. I started the regimen called DA-EPOCH-R. It is a 21-day cycle which consists of five days of treatment. I got continuous hours of chemo, and on the fifth day, I got two more infusions. I then had two weeks off. 

James

In 2001, my wife and I had not been able to get pregnant after five years of marriage. We decided to look into adoption. As part of the application process, we were required to go for routine bloodwork. Soon after, I got a call at my desk at work that I needed to see an oncologist. I was informed I had chronic myelomonocytic leukemia (CMML), a rare form of leukemia.

Holly

In February 2024, I had just entered my second trimester of pregnancy and woke up with a swollen lymph node on my neck about the size of a golf ball. After scans and two biopsies, I was diagnosed with diffuse large B-cell non-Hodgkin lymphoma (DLBCL). It was found to be high-grade (meaning it’s growing fast). This is an aggressive form of lymphoma, so I immediately began chemotherapy while pregnant. Waiting until after the baby was born for treatment (estimated six months later) was not in my best interest, and unfortunately, the risk of waiting was too high.

Heather

My name is Heather and I was diagnosed with acute myeloid leukemia (AML) +FLT3/ITD on December 14th, 2017. That morning I noticed I was extremely pale and I had large bruises over my body. My doctor ran blood work STAT and within an hour I knew my platelets were below 20 and I needed to rush to the ER. I was pretty near death at that time. I was in Disseminated Intravascular Coagulation (DIC), which has a pretty high mortality rate.

Exploiting tumor-immune dynamics to inform curative combination therapy for follicular lymphoma

Follicular lymphoma is a common form of blood cancer, affecting 15,000 new patients annually in the United States, but it remains incurable with conventional treatments. Bispecific antibodies represent a new class of therapies that engage the immune system to attack lymphoma cells and have shown promising effectiveness in inducing remissions in patients with this disease, but even they are unlikely to be curative.

Enhancing the “fitness” of anti-BCMA CAR T cells for improved efficacy in multiple myeloma

Chimeric antigen receptor (CAR) T cell therapy is a form of immune-based therapy where a patient’s own immune cells are genetically engineered to recognize and kill the tumor cells. This therapy has revolutionized the treatment of certain blood cancers and excitingly, two CAR T cell products were recently approved for the treatment of multiple myeloma.

William

The Leukemia and Lymphoma Society (LLS) holds a special place in my heart. I lost my mother to therapy associated with acute myeloid leukemia (AML) in July 2021. AML is a type of blood cancer that affects the bone marrow and blood. It can be very aggressive and progress rapidly without treatment. There are still certain forms of AML that do not have effective treatments, like the one my mother had. LLS was a resource I knew about from my work in solid tumor cancer research. It helped provide me with patient and caregiver resources that I needed at an extremely difficult time in my life.

Steven

I’m Steven, a 23-year-old who is no stranger to hard work and resilience. I juggle two jobs and live independently, but six months ago, my life took an unexpected turn when I was diagnosed with a rare form of non-Hodgkin lymphoma (NHL). In a heartbeat, I was thrown into a world of uncertainty, doctors’ appointments, and intensive treatments. I had to face radiation therapy, surgeries, and the challenge of missing work ― all while trying to keep life moving forward.

Michele

Bald is beautiful. Words and looks can be truly powerful. Positivity can change one’s opinion and most important of all, people. Surround yourself with people that make you cry that you’re laughing so hard, that make you smile for no reason, and leave your heart whole.

Dianne

When I was a little girl, I knew I wanted to be a nurse so I could help people. I did become a registered nurse, predominately in critical care settings. So, when you receive a disease diagnosis, you treat the problem…right? Not necessarily I have learned.

I was recently diagnosed with non-Hodgkin lymphoma (NHL). I felt as if I was tumbling down a dark, hot hole. “Not curable, treatable, lifelong”. This is “watch and wait” protocol diagnosis…an overwhelming concept…”watch and worry”, I was told, was another concept.

Dale

My husband, Dale, was first diagnosed with leukemia in October 2011, after we noticed a bubble under his chin. His chemo treatment lasted for four months, and in May of 2012, he was in remission. We were very excited to learn those results. He took his port out, and started living life again. Early in 2015, Dale was told his cancer was back, and the skin bubbles started to reappear. This meant another port and a different chemo treatment. It made him very sick, angry and depressed. It’s hard to watch your husband cry or shake cause he’s so cold and you just can’t keep him warm enough.

Jessica

Two years after surviving a massive heart attack, a heart transplant and a leg amputation at age 16, Jessica found a lump on her neck and was diagnosed with non-Hodgkin lymphoma (NHL). After months of treatment, her cancer was in remission.

Six years later, Jessica found another lump which out to be a different form of NHL. She told herself she'd been through cancer once before and there was no reason she couldn't beat it again. By January 2008, she was back in remission and finished treatment that following May.

Austin

In May 2011, when Kimberly Schuetz was starting to plan her son Austin’s third birthday, he was diagnosed with a high-risk form of acute lymphoblastic leukemia.

Austin was immediately placed on a chemotherapy regimen. However, when a routine blood test revealed that he relapsed in October 2012, their only option was a bone marrow transplant to save his life. After that transplant, his cancer came back for the third time in May 2013.

Layla

"Our LLS chapter has been there for us, with support and information that has helped immensely. We've formed a friends and family Ttam for the Light The Night Walk and it feels so rewarding to raise funds to help others who, like Layla, are bravely battling blood cancers." Alecia | Layla's mom

Lisa

It's not easy being bald, a bald physician, and a bald wife. This is my third dance with Hodgkin's Lymphoma (HL). I first met HL in college, as many young girls meet their first pivotal relationship. Sadly for me, I attended an all woman's college, so my pivotal 'boyfriend' came in the form of a first cancer diagnosis.