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2018 Nobel Prize in Physiology or Medicine: Unleashing the Immune System
The Nobel Prize in Physiology or Medicine has been awarded today to two scientists whose groundbreaking work led to the development of a class of immunotherapies called checkpoint inhibitors that work by releasing the brakes on the immune system.
Zanubrutinib
Zanubrutinib is indicated for the treatment of adult patients with:
Fludarabine
Fludarabine is FDA approved to treat people who have chronic lymphocytic leukemia (CLL) who have not responded to at least one standard alkylting-agent-containing regimen or whose disease has progressed during treatment with such a regimen. This medicine may rarely cause a temporary loss of hair. After treatment with fludarabine has ended, normal hair growth should return.
Lenalidomide
Lenalidomide is FDA approved to treat patients with:
Advances in Cancer Research and Treatment in 2020
Progress in new cancer treatments is accelerating so rapidly that the standard of care for many cancer patients is changing right before our very eyes.
Since 2017, the U.S. Food and Drug Administration (FDA) has approved a remarkable 53 therapies just to treat patients with blood cancers, and The Leukemia & Lymphoma Society (LLS) has helped advance 46 of these treatments.
I have no reason to believe the next few years won’t be as productive and groundbreaking as the last few. With that, here are some of my predictions for 2020:
Lisocabtagene maraleucel
Lisocabtagene maraleucel is indicated for the treatment of
Dr. Wu
Catherine Wu, M.D., is focused on chronic lymphocytic leukemia (CLL). One aspect of her research is to gain greater understanding of the genetic underpinnings of CLL. She and her colleagues are studying the role that a mutated gene – SF3BL - plays in the development of CLL in order to develop improved strategies to treat CLL. Another focus on her lab is to develop an immunotherapy approach to treating CLL. She is working on employing a CLL-specific antigen to develop a personalized vaccine for patients with CLL. Dr.
Jim
Stay focused, stay positive, live as life as normally as you did before diagnosis, and do your best.
Ask the Doctor Part 1: Five Questions about Leukemia
Leukemia Survivor, Myrrah Talks to Dr. Nichols about the Latest in Leukemia Research and Treatment
#ASH18: Beating AML
Sunday marked a significant milestone for The Leukemia & Lymphoma Society (LLS) and the patients we help. Here at the 60th American Society of Hematology (ASH) Annual Meeting in San Diego, a conference attended by more than 30,000 scientists from around the world, we unveiled the first results from our groundbreaking precision medicine Beat AML Master Clinical Trial. To date, more than 356 patients have been screened for this trial.
Sonia
In an instant, my life changed. “You have chronic lymphocytic leukemia (CLL). There is no cure but patients can live for several years.” These were the words I received a few years ago at the age of 39 with three small children. I have been on an educational journey of self-discovery, cancer research, and patient advocacy ever since.
George
I was born in the inner city of Philadelphia, PA in 1951, I currently live near Dallas, Texas. My professional career in the Information Technology Industry lasted over 40 years prior to my retirement in January 2019. In 2002 I was diagnosed with chronic lymphocytic leukemia (CLL) and many aspects of my life changed forever.
Dr. Brown
Jennifer Brown, M.D., Ph.D., who played a role in advancing ibrutinib for patients with chronic lymphocytic leukemia (CLL), is the recipient of an LLS Translational Research Program grant, and has previously received a career development program grant.
Her work is currently focused on studying the role that the Notch pathway plays in the development of CLL and whether therapies that target Notch can be effective for these patients.
Sue
My story begins with a routine yearly mammogram in April of 2020. I am currently a 25-year breast cancer survivor. So, regular mammograms are just a part of my yearly routine, a simple procedure that I endure yearly with no big issues to speak of ― until now. During the mammogram, they noticed enlarged lymph nodes. My doctor thought it was no big deal, and we would watch them for two weeks and then do another mammogram. I wasn’t worried. She explained that I could be fighting an infection or that I just had large lymph nodes as a normal thing.
Arturo Pierre
I’m 61 years old. I was diagnosed with chronic lymphocytic leukemia (CLL) the first time at 51, unaware of any symptoms. I was told that my diagnosis at my age was unusual. After chemotherapy and remission, the disease returned during COVID while I was being treated orally. The second experience was much worse. I’m in clinical remission for the second time in 10 years. Besides CLL, I wrestle with numerous orthopedic issues. I live an active lifestyle and maintain a healthy diet, exercise regularly, and work full time.
Douglas
My story begins almost 24 years ago in 1996, when I was diagnosed with cancer, chronic lymphocytic leukemia (CLL). Back then, there was no cure for CLL except for a bone marrow transplant (BMT), but that procedure only had a survival rate of 50%, not very attractive odds. My prognosis was I had anywhere from six to 15 years without a BMT.
Sara
Seeing Roses
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL)- Is a type of blood cancer that begins in the bone marrow
- Can progress either slowly or quickly depending on the form it takes
Click here to access CLL statistics.
Jayne & Jenny
My sister Jenny and I both have chronic lymphocytic leukemia (CLL), and I was doing the Facebook challenge, “50 Miles in November,” for The Leukemia & Lymphoma Society (LLS) in honor of us.
Todd
I was diagnosed at age 33 as a result of an unrelated blood test, very young, I was told. Fluorescence in situ hybridization (FISH) showed low risk. My local oncologist sent me to a regional teaching hospital to get a second opinion, and that opinion was, "If I had to pick a cancer, this would be it." Terrible start!
George
I am a 72-year-old retired Information Technology professional. I was diagnosed with chronic lymphocytic leukemia (CLL) in June 2002 and remain in active treatment today. Over the last 22 years, I have had more than 700 trips for doctor visits, treatments, lab test, emergency room, hospitalizations, and pharmacy. My biggest challenge over the years is managing the cost of premiums, medical treatment, drugs, travel, and medical appliances. I found multiple resources that stepped in to assist me with my financial challenges related to my CLL.
The History of Leukemia
Table of contents
Heather
The world works in mysterious ways, it truly does! When I first volunteered with The Leukemia & Lymphoma Society's (LLS) Team In Training (TNT) program in 2015, I never in a million years thought I would be fundraising in honor of my husband Dave. I started out fundraising for my step-grandmother Margaret and his grandmother Pearl. Eventually, the list of people I ran and fundraised in honor or memory of grew to way over 20! All that time it turns out I was fundraising for Dave, too, we just didn't know it yet!