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Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma (NHL)

Is a type of cancer that generally develops in the lymph nodes and lymphatic tissue found in organs such as the stomach, intestines or skin. In some cases, NHL involves bone marrow and blood.
Isn't just one disease–it's actually a diverse group of blood cancers that all arise from lymphocytes (white blood cells that are part of the immune system).
Lymphoma cells may develop in just one place or in many sites in the body.
NHL has many different subtypes which are either indolent (slow-growing) or aggressive (fast-grow

Doctors use physical examinations, imaging tests, blood test and, sometimes, bone marrow tests to determine the extent of the disease. This determination is called "staging." Staging provides important information for treatment planning.

Staging for Hodgkin lymphoma is based on the Lugano classification, which is derived from the Ann Arbor staging system.

Childhood Hodgkin Lymphoma

Because of new and better therapies, cancer survival rates for children have improved dramatically during the last several decades. Scientists continue to search for the causes of childhood lymphoma so they can develop better treatments with less toxic side effects.

Next-Generation Targeted Therapy in Mantle Cell Lymphoma and Transformed Follicular Lymphoma

The field of cancer treatment has made remarkable progress with the adoption of targeted therapy; however, small molecule drugs have limitations such as drug resistance and off-target toxicities. To overcome these challenges, we have developed an innovative approach that enhances the potency and precision of small molecule drugs. Our cutting-edge high-precision pretargeted nanoparticles can deliver potent triple inhibitors that effectively combat drug-resistant mantle cell lymphoma and dual proteolysis targeting chimeras (PROTACs) for treatment of transformed follicular lymphoma.

Cutaneous Lymphoma Foundation

To support every person with cutaneous lymphoma by promoting awareness and education, advancing patient care, and facilitating research.

Provides education and support to patients diagnosed with CL
Information on website is designed to help physicians, nurses and other health professionals access resources related to cutaneous lymphoma.

Anyone seeking information on cutaneous lymphoma (CL)

248-644-9014 http://www.clfoundation.org

International Resources

Canadian Resources International Resources U.S. Resources

Spotlight On T-Cell Lymphoma

T-cell lymphomas (TCL)

Follicular Lymphoma (FL)

Booklet Updates - Lymphoma

Living with Hodgkin Lymphoma

Lymphoma Foundation of America

To help lymphoma patients and families, and to fund research for a cure.

Registered nurses provide medical information and resources
Provides online list of lymphoma specialists in the US
Online survivor stories and lists of recommended books
Funds research grants and awards to scientists at leading universities and cancer centers.

Lymphoma patients, caregivers, healthcare professionals

734-222-1100 https://www.lymphomahelp.org/

International Resources

Canadian Resources U.S. Resources

Hodgkin Lymphoma (HL)

Spotlight On Hodgkin Lymphoma

Developing Novel Immunotherapies for Challenging Lymphomas

This team science program from Washington University will develop new immunotherapy treatments for patients with hard to treat or incurable lymphomas. The team includes physicians and scientists who have developed new ideas in the laboratory for immune-based treatment, and will translate these to clinical trial testing. These include engineered natural kill cells, healthy donors T cell engineered to attack a T cell lymphoma, and lymphoma-patient specific mutations as vaccine targets.

Translational Discovery in Peripheral T-Cell Lymphomas

Peripheral T-cell lymphomas (PTCLs) are poorly understood and patients with PTCL are underserved by current therapies. The most common subtypes (among >20) are PTCL-not otherwise specific (NOS), angioimmunoblastic T-cell lymphoma (AITL), and anaplastic large cell lymphoma (ALK- ALCL). Rational treatment strategies for these lymphomas are lacking, largely due to the insufficient characterization of PTCL pathobiology and historic paucity of faithful models.

Adolescent & Young Adult Cancer Awareness Week: Free Support & Financial Resources from The Leukemia & Lymphoma Society for Blood Cancer Patients, Survivors, Families & Caregivers

** The following article highlights free resources and programs that might be of particular interest to the young adult community; these are also available to all blood cancer patients, including the families and caregivers of adolescents with a blood cancer. We encourage parents/guardians of minors (up to age 18) to request a free copy of the “Caring for Kids And Adolescents With Blood Cancer” workbook by calling 800-955-4572 and to learn more below about ways LLS can help.

Childhood Non-Hodgkin Lymphoma

Role of ID2 in mature T-cell lymphoma

Overexpression of ID2 is a recurrent event in mature T-cell lymphoma (TCL), and its significance is yet to be established. We will use a multidisciplinary approach combining epigenetic, transcriptomic, and proteomic analysis in human and murine models to identify the mechanisms leading to ID2 overexpression and their effect on T-cell transformation. Our goal is to define the role of ID2 in lymphomagenesis and determine its potential as a novel therapeutic target in TCL.

Targeting mutant IDH2 in angioimmunoblastic T-cell lymphoma

Angioimmunoblastic T-cell lymphoma is a rare, aggressive form of T-cell lymphoma associated with poor clinical outcomes in response to current therapeutic approaches. Recurrent oncogenic mutations in isocitrate dehydrogenase 2 (IDH2) have been identified in patients with angioimmunoblastic T-cell lymphoma and this represents a targetable lesion in other malignancies. However, comprehensive investigations of mutant IDH2 inhibition in angioimmunoblastic T-cell lymphoma are lacking, and this may represent a new therapeutic avenue for a patient population in need of newer treatments

Analysis and therapeutic targeting of the immune regulatory and ubiquitination pathways in Anaplastic Large Cell Lymphoma and Hodgkin Lymphoma

My lab is focused on the immune regulatory mechanisms and ubiquitin-dependent machinery in lymphoma. We have established multiple high-throughput screening technologies and animal models to rapidly and accurately identify critical pathways that are suitable for targeted therapy and immunotherapy. Gaining insight into the pathological roles of these pathways can lead to improved understandings of the molecular circuitry that drives lymphoma pathogenesis and provide novel therapeutic strategies.

The Follicular Lymphoma Foundation Joins Forces With The Leukemia & Lymphoma Society to Bring Hope to Those Living With Follicular Lymphoma

Targeting Microenvironment Determinants in Peripheral T-cell Lymphoma

Peripheral T-cell lymphomas are highly aggressive blood cancer that have very poor survival rate, highlighting the need for new therapies to improve patient survival. We aim to improve our understanding of the characteristics of the individual cancer cells and their interaction with surrounding cells in the tumor environment with the goal of identifying new drugs that we can validate in preclinical models and move into more efficient treatments for lymphoma patients.

T-Cell Leukemia Lymphoma Foundation

To provide education and support to patients and to encourage research into these rare cancers

Provides disease, treatment and clinical trial information for the T-cell leukemias and lymphomas
Organizes free educational forums
Offers physician referrals, e-newsletter and links to helpful resources
Supports scientific research on the T-cell leukemias and lymphomas.

Patients, caregivers, healthcare professionals, researchers

Website or 206-661-2253 http://www.tcllfoundation.org/

Lymphoma Research Foundation (LRF)

To realize the promise of science to eradicate lymphoma and serve the community touched by this disease.

Provides Lymphoma Helpline and Clinical Trials Information Service
Provides educational materials, conferences, webcasts
Offers limited financial assistance to patients in active treatment
Lymphoma Support Network is a one-to-one peer support program that matches lymphoma patients or caregivers with volunteers who have had similar lymphoma-related experiences
Funds biomedical research focused on the origins, treatment and identification of a cure for lymphoma
Raises public awareness of the disease.

Patients with lymphoma and their families, caregivers, health professionals

800-500-9976 https://lymphoma.org/

International Resources

International Resources

Why: A Memoir of Love and Lymphoma

Why: A Memoir of Love and Lymphoma by John Melithoniotes
NFB Publishing, 2023, 278 Pages, Paperback or Kindle
ISBN: 9781953610485

There is no test of a couple’s bonds like the revelation that one of them has a life-threatening disease. One of them, a husband, wife, or partner, will become a patient who may need care from the other almost constantly. This is the story of John and Marilyn, whose love of nearly forty years encounters a diagnosis of Marilyn’s Non-Hodgkin’s lymphoma. John’s memoir describes the complexities of how they navigated their way through a large urban cancer hospital, their daily attempts to manage the side effects of chemotherapy, and their emotional struggle to cope with a worsening crisis. He revisits key scenes from their lives in the hope of understanding their actions and the surprises in store for both of them.

For more information click here

Suggested Reading-Why: A Memoir of Love and Lymphoma

Audience

Adults

Subject

Caregiving Decision Making Grief Inspiration Living with Cancer/Survivorship Side Effects Treatments