LLS Research Spotlight

Highlighting brand new publications and advances produced by LLS-funded blood cancer research.

Welcome to LLS Research Spotlight!

This is your connection to the latest in LLS Research. LLS-funded researchers are making strides toward new therapies and pathways to cures for blood cancers. We're highlighting some of these researchers with detailed summaries of their latest publications and success stories, designed to give you an idea of the latest happenings in blood cancer research.

The LLS Research Spotlight is brand new, but there's plenty more to come! Check back soon or follow us on Twitter @LLSResearch for updates.


 

Spotlight Articles

Coordination of Distinct Pathways Drives AML in a Subset of Patie...

Various cellular events may lead to cancer. These include DNA mutations that change a protein’s structure as well as alterations that change the way genes are expressed.  A team led by Dr. Abdel-Wahab at Memorial Sloan Kettering Cancer Center recently published research showing a connection between specific mutations and how certain genes are expressed in acute myeloid leukemia (AML). They show that ...

Discovery Links Molecular Pathways for Therapeutic Possibilities ...

New discoveries from Dr. Jian Xu’s laboratory uncover several promising therapeutic possibilities for a specific type of myeloproliferative neoplasms (MPNs). His work elucidates the ways by which epigenetic and signaling pathways’ cooperation can affect metabolism and contribute to disease development. Specifically, the epigenetic modifier EZH2 and signaling agent NRAS can work together through different mechanis...

Sports Analytics Model Adapted to Improve Cancer Outcome Predicti...

Ash Alizadeh, Maximilian Diehn, and their team have developed and tested a new dynamic method for predicting cancer patient outcomes, called Continuous Individualized Risk Index (CIRI), which is modeled after algorithms used for outcome prediction in sports and politics. They have determined that CIRI is more accurate than current predictive methods in both blood cancers and solid tumors. The info...

Genotyping of Transcriptomes: A Breakthrough Technology in Single...

Though a patient’s cancer is treated as a single disease, it is made up of a diverse collection of cells that are related but may have distinct characteristics. When mutations occur in cells and are passed down to daughter cells, new subclonal populations are created in the bulk cancer population. Each subclonal population has a distinct mutational profile. In order to fully understand each patient’s cancer, we r...

Age-Related AML Risk: An Exploration of Hematopoietic Stem Cell E...

The population of elderly people is increasing both in the United States and worldwide, and this increase presents challenges in addressing the medical risk factors associated with aging, including an increased risk of developing acute myeloid leukemia (AML). New research out of the laboratory of Maria "Ken" Figueroa, Associate Professor and Co-Leader of the Cancer Epigenetics Research Program at University of Miami ...

Evolutionary Behavior in CLL: Implications for Personalized Thera...

In recent years, there has been a rapid surge in the amount of genomic information available to researchers. This information enhances the understanding of human disease and provides the fuel needed to achieve personalized medicine. New advances in technology and in the ability to analyze massive datasets have allowed scientists to more precisely define cancer behavior, including how these diseases adapt to evade the...