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Side Effects

Cancer therapy for juvenile myelomonocytic leukemia (JMML) can sometimes produce side effects. For most patients, treatment side effects are temporary and go away once therapy ends. For others, side effects can be more severe, sometimes requiring hospitalization. Some patients never have side effects.

Before your child undergoes treatment, talk with his or her doctor about potential side effects. Drugs and other therapies can prevent or manage many side effects.

Reduced-Intensity Allogeneic Stem Cell Transplantation

Reduced-intensity allogeneic stem cell transplantation (sometimes called mini-transplant or nonmyeloablative transplant), like a standard allogeneic stem cell transplantation, uses stem cells from a donor, but the conditioning treatment contains lower, less toxic doses of chemotherapy and radiation. This type of SCT may be an option for certain patients who are older or who are otherwise not healthy enough or strong enough to undergo standard allogeneic SCT.

Lisa

I noticed some lymph nodes popped up on my neck so I went to the Dr. I didn't feel bad at all. My Dr ordered blood work and my white blood count was high. I was sent to The Cancer Center of Acadiana and more blood work, scans, ultrasound and bone biopsy was done. After all the results came in my white blood count was 99,000 and I had 75% leukemia cells in my bone marrow. I was diagnosed with CLL. 4 days later I was in the Infusion room at The Cancer Center of Acadiana. After 5 months of chemo going 2 days every month I am leukemia free.

Cooper

I am Cooper, and I am a leukemia survivor. I am 26 and creating businesses around the creativity space. I am a healer and author of multiple books. I was diagnosed with leukemia at the age of seven. I did treatment for 2½ years with chemotherapy. I have been in remission for 16 years. I am grateful to be here. I have donated around $100,000 to The Leukemia & Lymphoma Society (LLS). I have done Pennies for Patients (PFP), Student Of The Year (SOY), and been an Honored Hero for multiple events. My high school raised $10,000 in one week for PFP.

James

In 2001, my wife and I had not been able to get pregnant after five years of marriage. We decided to look into adoption. As part of the application process, we were required to go for routine bloodwork. Soon after, I got a call at my desk at work that I needed to see an oncologist. I was informed I had chronic myelomonocytic leukemia (CMML), a rare form of leukemia.

Side Effects

Most ALL treatment side effects are temporary and subside once the body adjusts to therapy or after the therapy is completed. If side effects become severe, children may need to be hospitalized.

Side effects common to ALL and its treatment include:

Chemotherapy

Chemotherapy is the main treatment for ALL. The phases of treatment include the following:

The first phase of chemotherapy is called “induction therapy.” Induction therapy

Nicole

I first became involved in Team In Training (TNT) and The Leukemia & Lymphoma Society (LLS) in March of 2020 because I was very interested in running the New York City Marathon. I knew that I wanted to run for a charity that meant something to me, so I knew I had to be a part of this team.

Signs and Symptoms

The signs and symptoms of acute myeloid leukemia (AML) are common to other, less serious illnesses. However, if you're troubled by any of the following symptoms, see your doctor: 

It is common for people with AML to feel a loss of well-being because of the underproduction of normal bone marrow cells. 

Symptoms of a low red blood cell count (called “anemia”) include:

Treatment Outcomes

AML is a difficult disease to cure. Just a few decades ago, almost no adults with AML could be cured. But today, advances in understanding of the genetic features of the disease and the use of targeted therapies have resulted in improved remission and cure rates for AML patients.

For statistics, click here.

• Download or order The Leukemia & Lymphoma Society's free booklet, Acute Myeloid Leukemia in Adults.

Side Effects

Therapy for acute lymphoblastic leukemia (ALL) can produce side effects. For most patients, treatment side effects are temporary and go away once therapy ends. For other patients, side effects can be severe, sometimes requiring hospitalization.

Before you start treatment, talk with your doctor about potential side effects. Drugs and other therapies can prevent or manage many side effects. Many treatment side effects go away or become less noticeable over time.

The side effects you may experience depend on:

Kayli

My daughter Kayli is a remarkable 22-year-old, six-time cancer survivor of leukemia who is currently undergoing treatment for a relapse of acute lymphoblastic leukemia (ALL) that has been recurrent in her central nervous system (CNS) since she was 8 years old. We are hopeful that the upcoming bone marrow transplant will provide a much-needed, life-saving cure for Kayli.

I am an RN and a single mother of five daughters and one son. My only son, Kayli's brother, Markai, is a full match and will be her bone marrow donor. He just graduated high school in May.

Katharine

My mother, Nancy, was diagnosed with acute myeloid leukemia (AML) with a FLT3 mutation in March 2022. Over the next year and a half, she went through multiple rounds and regimens of inpatient and outpatient chemotherapy. At every step along the way, every member of my mom's care team kept mentioning how the outlook for patients like my mom was so much better now than it had been even 10 years ago thanks to advances in medicine.

Riley

On October 17, 2023, my life took a turn I never saw coming. My doctor sat me down and told me, "You have leukemia." It felt like the ground had shifted beneath my feet. I was scared, couldn't believe it was happening, and had no idea what the future held.

Sandy

In the summer of 2006 I received a letter in the mail much like what you get around the holidays telling of the adventures over the past year.  My friend had recently moved to Tucson with her family.  She shared pictures of their kids and told about the transition from the Seattle area to Tucson.

Kent

When Noah was born in 2005, we were surprised when the doctor told us he had Down syndrome.  Soon after, we were informed about all of the things that Noah wouldn’t or couldn’t do in his lifetime.  We were also given a laundry list of medical problems that he could potentially have.  Two months after he was born, Noah went into heart failure and had open heart surgery to correct four holes in his heart.  This was a tough time but boy did we have more to come and didn’t know it.  He has since had multiple surgeries, tests, studies, etc.  We were told that Noa

Treatment

It's important that your doctor is experienced in treating patients with chronic leukemia or works in consultation with a chronic lymphocytic leukemia (CLL) specialist. This type of specialist is called a hematologist oncologist.

Current therapies do not offer patients a cure for CLL, but there are treatments that help manage the disease. Doctors use several types of approaches and treatment for adults with CLL, some at different stages:

Treatment

It's important that your doctor is experienced in treating people who have chronic myelomonocytic leukemia (CMML) or works in consultation with a hematologist oncologist who has experience treating CMML patients.

In most cases, CMML can't be cured, but it can be treated. Doctors use several types of treatment for adults with CMML, although there's no one standard drug therapy for the disease:

Childhood ALL

Because of new and better therapies, cancer survival rates for children have improved dramatically during the last several decades. Scientists continue to search for the causes of childhood leukemia so they can develop better treatments with less toxic side effects.

Signs and Symptoms

People who have chronic myeloid leukemia (CML) may not have any symptoms at first. Often, patients learn they have CML after a routine physical exam or a blood test. CML signs and symptoms tend to develop gradually. Those with symptoms often report experiencing: 

Debbie

My only child was my heart and soul!  He was a son to be proud of in so many ways.  Kind, gentle, and caring was only the tip of the iceberg to his character.  He had lots of friends and was always ready to help when called.  He had just finished his freshman year in college when he was diagnosed with Hodgkin lymphoma.  It changed our world.

Austin

In May 2011, when Kimberly Schuetz was starting to plan her son Austin’s third birthday, he was diagnosed with a high-risk form of acute lymphoblastic leukemia.

Austin was immediately placed on a chemotherapy regimen. However, when a routine blood test revealed that he relapsed in October 2012, their only option was a bone marrow transplant to save his life. After that transplant, his cancer came back for the third time in May 2013.

Shaden

Shaden is fighting against leukemia. He is three years old and was a healthy boy before his diagnosis. Then, out of nowhere, he would get a lot of body aches that were very unusual.

Sometimes Shaden didn’t feel like being the happy, energetic kid he always was. He wouldn’t walk, sleep or eat. We decided to take Shaden to the children’s hospital and they did some testing. They soon told us that he might have leukemia. They did more testing, and Shaden was diagnosed with acute myeloid leukemia (AML).

Diagnosis

Diagnosing chronic myelomonocytic leukemia (CMML) usually involves a series of repeated tests, including blood and bone marrow tests. Your doctor usually can't confirm a diagnosis of CMML with one lab test result that shows abnormal blood counts. Instead, he or she will monitor you over a period of time with repeated lab tests that show abnormal blood counts. This is done to rule out other diagnoses.

Bone marrow testing involves two steps usually done at the same time in a doctor's office or a hospital:

Radiation Therapy

Radiation therapy uses X-rays or other high-energy rays to kill cancer cells. Radiation therapy is sometimes used to treat a person with CLL who has an enlarged (swollen) lymph node, spleen, or other organ that is blocking the function of a neighboring body part, such as the kidney or the throat.