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Signs and Symptoms

Signs and symptoms vary from patient to patient and depend on the type of CMML. Click here to learn more about subtypes of CMML. 

Those with a myelodysplastic subtype (MD-CMML) tend to present with low blood cell counts. Signs and symptoms may include:

  • Weakness and fatigue due to anemia (a condition in which blood lacks adequate healthy red blood cells to carry sufficient oxygen throughout the body)
  • Petechiae (pinhead-sized sites of bleeding in the skin), bruising and bleeding due to thrombocytopenia (low platelet counts)
  • Recurrent infections due to leukopenia (a below normal white blood cell count)

Patients with a myeloproliferative subtype (MP-CMML) tend to have high blood cell counts. Signs and symptoms may include:

  • Enlargement of the spleen and liver
  • A feeling of fullness below the ribs due to spleen enlargement
  • Fatigue
  • Drenching night sweats
  • Bone pain
  • Weight loss

The signs and symptoms of chronic myelomonocytic leukemia (CMML) are common to other, less serious illnesses. However, if you're troubled by any of the following symptoms, see your doctor.

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