Children who have juvenile myelomonocytic leukemia (JMML) may have the following signs and symptoms:

• Enlarged liver, enlarged spleen and enlarged lymph nodes
• Pale appearance
• Fever
• Rash.

Other symptoms and signs that have been described are developmental delay, decrease in appetite, irritability, dry cough, fatigue, weight loss, recurrent infections, abdominal pain, and bone and joint pain.