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Ruxolitinib

Details of the Drug
Generic Name:
Ruxolitinib
Pronunciation:
RUX-soh-LI-ti-nib
Drug Type:
Janus-associated kinase inhibitor
How the Drug is Given:

By mouth

Names:
Jakafi®
Ruxolitinib

Indications and Usage

Ruxolitinib is FDA approved for treatment of  

  • Intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis in adults
  • Polycythemia vera in adults who have had an inadequate response to or are intolerant of hydroxyurea
  • Steroid-refractory acute graft-versus-host disease in adult and pediatric patients 12 years and older. 

Side effects needing medical attention

Bruising; dizziness; headache; urinary tract infection; weight gain; flatulence; herpes zoster; low platelet counts; low red blood cell counts; low white blood cell counts. 

Tuberculosis has been reported in patients receiving ruxolitinib for myelofibrosis.

Progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection that can result in death, has been reported with ruxolitinib treatment for myelofibrosis. 

For information on how to manage the costs of drug therapy, please see Financial Support, or to speak with an Information Specialist, call (800) 955-4572.