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Rituximab

Details of the Drug
Generic Name:
Rituximab
Pronunciation:
rih-TUK-si-mab
Drug Type:
Monoclonal antibody
How the Drug is Given:

Intravenously (IV)

Names:
Rituxan®
Rituximab
Rituximab-abbs
Rituximab-pvvr
Ruxolitinib
Ruxience™

Indications and Usage

is FDA approved for the treatment of adult patients with:

  • Non-Hodgkin lymphoma (NHL)
    • Relapsed or refractory, low grade or follicular, CD20-positive Bcell NHL as a single agent.
    • Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete or partial response to RITUXAN in combination with chemotherapy, as single-agent maintenance therapy.
    • Non-progressing (including stable disease), low-grade, CD20- positive, B-cell NHL as a single agent after first-line cyclophosphamide, vincristine, and prednisone (CVP) chemotherapy.
    • Previously untreated diffuse large B-cell, CD20-positive NHL in combination with (cyclophosphamide, doxorubicin, vincristine, and prednisone) (CHOP) or other anthracycline-based chemotherapy regimens. 
  • Chronic lymphocytic leukemia (CLL)
    • Previously untreated and previously treated CD20-positive CLL in combination with fludarabine and cyclophosphamide (FC).

Side effects needing medical attention

Fever; chills; difficulty breathing or shortness of breath; sensation of tongue or throat swelling; hives; itching; weakness; headache; nausea; vomiting; flushing; palpitations; chest pain; rash; dizziness; coughing; unusual tiredness or fatigue; unusual bruising or bleeding; muscle or joint pain; abdominal pain; diarrhea.

In patients with prior hepatitis B (HBV) infection, HBV reactivation may occur when the body's immune system is impaired.

For information on how to manage the costs of drug therapy, please see Financial Support, or to speak with an Information Specialist, call (800) 955-4572.