Luspatercept-aamt

Details of the Drug

Generic Name:: Luspatercept-aamt
Drug Type:: Erythroid maturation agent
How the Drug is Given:: Injection, for subcutaneous use
Names:: Reblozyl®; Luspatercept-aamt

Indications and Usage

Luspatercept-aamt is FDA approved for the treatment of anemia failing an erythropoiesis stimulating agent and requiring 2 or more red blood cell (RBC) units over 8 weeks in adult patients with very low- to intermediate-risk myelodysplastic syndromes with ring sideroblasts (MDS-RS) or with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T).

Limitations of Use: Reblozyl is not indicated for use as a substitute for RBC transfusions in patients who require immediate correction of anemia.

Side effects needing medical attention

The most common adverse reactions were fatigue, headache, musculoskeletal pain, pain in a joint (arthralgia), dizziness/vertigo, nausea, diarrhea, cough, abdominal pain, difficulty breathing (dyspnea), and hypersensitivity.

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