Ivosidenib

Details of the Drug
Generic Name:
Ivosidenib
Pronunciation:
I-voh-SIH-deh-nib
Drug Type:
Isocitrate dehydrogenase-1 (IDH1) inhibitor
How the Drug is Given:

By mouth

Names:
Tibsovo®
Ivosidenib

Indications and Usage

Ivosidenib is FDA approved for the treatment of acute myeloid leukemia (AML) with a susceptible IDH1 mutation as detected by an FDA-approved test in:

  • Newly diagnosed acute myeloid leukemia (AML)
    • In combination with azacitidine or as monotherapy for the treatment of newly diagnosed AML in adults 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy 
  • Relapsed or refractory AML
    • For the treatment of adult patients with relapsed or refractory AML

Side effects needing medical attention

Fatigue, increased number of leukocytes (white blood cells) (leukocytosis), joint pain, diarrhea, difficulty breathing, excess of fluid in cavities or tissues of the body (edema), nausea, painful inflammation and ulceration of the mucous membranes lining the digestive tract (mucositis), electrocardiogram QT prolonged, rash, fever, cough, and constipation.

For information on how to manage the costs of drug therapy, please see Financial Support, or to speak with an Information Specialist, call (800) 955-4572.