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Details of the Drug
Generic Name:
Drug Type:
Growth factor
How the Drug is Given:

Subcutaneous (SC) injection or intravenously (IV)

Zarxio™ *
Nivestym™ *

Indications and Usage

Filgrastim is FDA approved to 

  • Decrease the incidence of infection‚ as manifested by febrile neutropenia‚ in patients with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever
  • Reduce the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia (AML)
  • Reduce the duration of neutropenia and neutropenia-related clinical sequelae‚ e.g.‚ febrile neutropenia, in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation (BMT)
  • Mobilize autologous hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis
  • Reduce the incidence and duration of sequelae of severe neutropenia (e.g.‚ fever‚ infections‚ oropharyngeal ulcers) in symptomatic patients with congenital neutropenia‚ cyclic neutropenia‚ or idiopathic neutropenia
  • Increase survival in patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Syndrome of Acute Radiation Syndrome)


Side effects needing medical attention

Aching in the bones and muscles; spleen rupture; acute respiratory distress syndrome (ARDS); serious allergic reactions; sickle cell crisis; kidney injury; Capillary Leak Syndrome; decreased platelet count (thrombocytopenia); increased white blood cell count (leukocytosis); inflammation of your blood vessels (cutaneous vasculitis).

*A biosimilar is a biological product that is highly similar to and has no clinically meaningful differences from an existing FDA-approved reference product. Click here for more information. 

For information on how to manage the costs of drug therapy, please see Financial Support, or to speak with an Information Specialist, call (800) 955-4572.