Crizotinib

Details of the Drug

Generic Name:: Crizotinib
Drug Type:: Kinase inhibitor
How the Drug is Given:: By mouth
Names:: Xalkori®; Crizotinib

Indications and Usage

Crizotinib is FDA approved for the treatment of pediatric patients 1 year of age and older and young adults with relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive.

Limitations of Use: The safety and efficacy of Xalkori have not been established in older adults with relapsed or refractory, systemic ALK-positive ALCL.

Side effects needing medical attention

The most common adverse reactions in patients with ALCL, excluding laboratory abnormalities, are diarrhea, vomiting, nausea, vision disorder, headache, musculoskeletal pain, stomatitis, fatigue, decreased appetite, fever, abdominal pain, cough, and pruritus. Grade 3-4 laboratory abnormalities are neutropenia, lymphopenia, and thrombocytopenia.

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