Cobimetinib

Indications and Usage

Cobimetinib is indicated as a single agent for the treatment of adult patients with histiocytic neoplasms.

Side effects needing medical attention

Most common adverse reactions are acneiform dermatitis (A skin condition that causes small, raised, acne-like bumps to form, usually on the face, scalp, chest, and upper back), diarrhea, infection, fatigue, nausea, edema (swelling caused by excess fluid trapped in your body's tissues), dry skin, maculopapular rash (a type of rash characterized by a flat, red area on the skin that is covered with small confluent bumps), pruritus (itchy skin), dyspepsia (recurring signs and symptoms of indigestion that have no obvious cause), vomiting, dyspnea (difficulty breathing) and urinary tract infections. 

The most common lab abnormalities include: Hyponatremia (concentration of sodium in your blood is abnormally low), increased blood creatine phosphokinase, hypokalemia (metabolic imbalance characterized by extremely low potassium levels in the blood), increased blood creatinine (may be a sign of poor kidney function), increased AST (sign of liver damage), hypocalcemia (levels of calcium in your blood are too low), lymphopenia (the blood doesn't have enough white blood cells called lymphocytes), leukopenia (low white blood cell count), anemia (low red blood cell count).