Dr. Tyler Parsons completed his PhD research at Oakland University and the Beaumont Research Institute in the lab of Dr. Gerard Madlambayan where he published on the role of blood stem cells in tumor response to radiation therapy. During the final year of his PhD, he was diagnosed with a myeloproliferative neoplasm (MPN) which directed his career focus and passion to furthering the understanding of MPNs and their transformation potential to leukemia. To this end, he joined the lab of Dr. Grant Challen at Washington University School of Medicine (St. Louis) where he is investigating clonal evolution in MPNs and the mutational trajectory leading to secondary leukemia. The aim of his post-doctoral fellowship is to describe the clonal architecture of MPN disease progression to leukemia which could lead to early detection and improved disease surveillance. He is passionate about improving outcomes for patients by advancing our understanding of both the biology and disease evolution of MPNs.