Randall Davis, MD
The University of Alabama at Birmingham
A graduate of Boston University, Dr. Davis completed medical school at the University of Alabama School of Medicine, where he also served his internship, residency, and the ABIM academic subspecialty research fellowship clinical investigator pathway in Hematology/Oncology. He is Professor of Medicine, is board certified in Hematology, and serves as the director of the UAB CLL Program. His laboratory studies the cellular and molecular immunobiology of lymphocytes in healthy and malignant conditions. As a postdoctoral fellow, he co-discovered a multigene family termed Fc receptor-like (FCRL1-6) that encodes cell surface proteins with tyrosine-based signaling function that are restricted to lymphocytes and upregulated in malignancies. Novel panels of antibodies and mouse models have been generated to investigate FCRL translational biology. The current proposal extends nearly two-decades of studies to advance immunotherapeutic targeting of the FCRL1 member in CLL and B cell malignancies.