Kathleen Sakamoto, PhD, MD
Palo Alto, CA
Dr. Kathleen Sakamoto is Professor of Pediatrics at Stanford University School of Medicine. She has been studying the causes of AML and developing new therapies for the past 30 years. Her research funded by the LLS currently focuses on repurposing a drug used to treat tapeworms, niclosamide, for children with relapsed/refractory AML. Niclosamide is an FDA approved drug and is well tolerated in children. Dr. Sakamoto’s research has resulted in a Phase I clinical trial that will study toxicity, response in AML cells, and drug levels. She is also studying mechanisms of resistance of AML cells to niclosamide to look for drugs that will act synergistically for future clinical trials. Her goal is to take discoveries in the laboratory and translate them to the clinics to improve the overall survival and quality of life in children with AML.