MF usually develops slowly. About one-third of people with myelofibrosis (MF) have no symptoms at the time of diagnosis. Patients often learn they have MF after a routine physical exam and blood test.
When MF signs and symptoms do appear, they can include:
- Tiredness, weakness, shortness of breath, usually due to a low red blood cell count (anemia)
- Pain or a feeling of fullness below the ribs on the left side, as a result of an enlarged spleen (splenomegaly)
- Enlarged liver (on the right side of the abdomen below ribs)
- Pale skin
- Easy bleeding or bruising, as a result of a low platelet count (thrombocytopenia)
- Excessive night sweats
- Frequent infections, due to a low white blood cell count (neutropenia)
- Bone or joint pain
- Weight loss
See your doctor if you're troubled by any of the above signs or symptoms.