- Generic Name:
- Drug Type:
- Kinase inhibitor
- How the Drug is Given:
Indications and Usage
Umbralisib is a indicated for the treatment of adult patients with:
- Relapsed or refractory marginal zone lymphoma (MZL) who have received at least one prior anti-CD20-based regimen
- Relapsed or refractory follicular lymphoma (FL) who have received at least three prior lines of systemic therapy.
These indications are approved under accelerated approval based on overall response rate. Continued approval for these indications may be contingent upon verification and description of clinical benefit in a confirmatory trial.
Side effects needing medical attention
The most common adverse reactions were increased creatinine, diarrhea, fatigue, nausea, neutropenia (low white blood cell count), transaminase elevation, musculoskeletal pain, anemia, thrombocytopenia (low platelet levels), upper respiratory tract infection, vomiting, abdominal pain, decreased appetite, and rash