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Pediatric AML PDX Models and Drug Testing-Gateway to Novel PedAL Trials

Alexandra Stevens

Alexandra Stevens


Baylor College of Medicine

Project Term: July 1, 2021 - June 30, 2023

Pediatric AML is a disease with poor outcomes and a need for improved therapeutic options. Pediatric AML is characterized by diverse lesions that often do not overlap with adult AML, which therefore means therapeutic development must be done using pediatric AML models. Recent advances in patient derived xenograft (PDX) modeling have made possible the successful development of PDX models of diverse pediatric AML subtypes.

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