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CRISPR-based functional characterization of WM cells: insights into therapeutic vulnerabilities and strategies to overcome resistance

Constantine Mitsiades

Constantine Mitsiades


Dana-Farber Cancer Institute

Project Term: October 1, 2019 - October 1, 2021

This project represents the first, to our knowledge, systematic effort to apply CRISPRCas9-based functional genomics approaches to determine in an unbiased manner (i) which genes are essential for survival/proliferation of Waldenstr├Âm's Macroglobulinemia (WM) cells and have distinct vs. shared roles for WM vs. other hematologic malignancies (e.g. multiple myeloma, MM); and (ii) which genes drive WM cell resistance to established or investigational therapies.

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