Constantine MitsiadesPhD, MD
Dana-Farber Cancer Institute
Project Term: October 1, 2019 - October 1, 2021
This project represents the first, to our knowledge, systematic effort to apply CRISPRCas9-based functional genomics approaches to determine in an unbiased manner (i) which genes are essential for survival/proliferation of Waldenström's Macroglobulinemia (WM) cells and have distinct vs. shared roles for WM vs. other hematologic malignancies (e.g. multiple myeloma, MM); and (ii) which genes drive WM cell resistance to established or investigational therapies.