Charles Mullighan is a member of the Department of Pathology, Co-leader of the Hematologic Malignancies Program, and Deputy Director of the Comprehensive Cancer Center at St Jude Children’s Research Hospital. Professor Mullighan’s research examines the genetic determinants of leukemogenesis and treatment response in acute lymphoblastic leukaemia(ALL) and high risk leukemias. His work has defined the genetic pathogenesis of multiple new subtypes of ALL,andseveral genetic alterations that have entered the clinic as new diagnostic and therapeutic targets. He is the recipient of numerous awards including an National Cancer Institute Outstanding Investigator Award, the Meyenburg Prize for Cancer Research and the American Society of Hematology Dameshek Prize.