Researchers & Healthcare Professionals

Significance of the Tumor Microenvironment in Hematological Malignancies

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Date: December 3, 2010
Credit Available Until: January 20, 2012
Target Audience: Hematologists, oncologists, nurses, social workers and other healthcare professionals
Access: Virtual Lecture

Activity Purpose

This activity is designed to educate hematologists, oncologists, nurses, social workers and other healthcare professionals on the evolving role of the tumor microenvironment in the pathogenesis and management of various malignancies.

Educational Objectives

After completing this activity, the participant should be better able to:

  • Explain the complex interactions between stromal cells and tumor cells
  • Discuss the role of bone marrow microenvironment in leukemia stem cell survival
  • Describe the mechanisms by which bone marrow stroma can confer net chemotherapy resistance in diverse hematologic malignancies
  • Discuss the therapeutic potential of targeting one or more stromal components to reverse malignant cell resistance to chemotherapy and improve clinical outcomes for hematologic malignancies


Iannis Aifantis, Ph.D.
Associate Professor, Department of Pathology
New York University School of Medicine Co-Director, Cancer Stem Cell Program
New York University Cancer Institute
Early Career Investigator
Howard Hughes Medical Institute
New York, NY

Michael P. Rettig, Ph.D.
Research Assistant Professor of Medicine
Section of Bone Marrow Transplant
Division of Oncology
Washington University School of Medicine
St. Louis, MO

Irene M. Ghobrial, M.D.
Director of Laboratory
Dana-Farber Cancer Institute
Assistant Professor, Department of Medicine
Harvard Medical School
Boston, MA

Sean J. Morrison, Ph.D.
Director, University of Michigan Center for Stem Cell Biology
Professor, Departments of Internal Medicine and Cell and Developmental Biology
Research Professor, Life Sciences Institute
Investigator, Howard Hughes Medical Institute
University of Michigan
Ann Arbor, MI

Louis M. Staudt, M.D., Ph.D.
Deputy Chief, Metabolism Branch
Center of Cancer Research
National Cancer Institute
National Institutes of Health
Bethesda, MD

Sponsors and Supporters

This activity was jointly sponsored by Robert Michael Educational Institute LLC and Postgraduate Institute for Medicine, and is supported by educational grants from Millennium Pharmaceuticals, Inc., Celgene Corporation and Allos Therapeutics.

last updated on Friday, March 23, 2012



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