Free Publications

Search for cll returned 203 results

Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.

Venetoclax

Generic name Venetoclax Brand name(s), other common name(s) Venclexta® Drug type   BCL-2 inhibitor How the drug is given By mouth Indications and Usage Venetoclax is FDA approved for the treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who have received at least one prior therapy.
  Side ef ...

  • Photo
Read more

Treatment

It's important that your doctor is experienced in treating patients with chronic leukemia or works in consultation with a chronic lymphocytic leukemia (CLL) specialist. This type of specialist is called a hematologist oncologist.   Types of CLL Treatment Current therapies do not offer patients a cure for CLL, but there are treatments that help manage the disease. Doctors use several types of approaches and treatment for adults with CLL, some at different stages: Watch an ...

  • Photo
Read more

Disease Complications

Chronic lymphocytic leukemia (CLL) may cause complications such as those outlined below.   Infection Infection is a common complication for people with CLL. Because of the high risk of infections, immediate vaccination for pneumococcal pneumonia with Prevnar 13® and a yearly flu vaccine is recommended. CLL patients do not respond well to vaccines due to their immune system depression. CLL patients should never receive live vaccines (such as the shingles vaccine). ...

  • Photo
Read more

Radiation Therapy

Radiation therapy uses high-energy rays to destroy cancer cells. It is typically not part of standard CLL treatment but it is sometimes used to shrink an enlarged spleen, large lymph node masses, or masses in locations that interfere with the function of a neighboring body part, such as the kidney, the gastrointestinal tract or the throat. It can also be helpful in treating pain from bone damage caused by leukemia growing in the marrow. This type of therapy is rarely used in CLL.

  • Photo
Read more

Signs and Symptoms

Many people are diagnosed with CLL even though they do not have any symptoms. The disease may be suspected because of abnormal results from blood tests that were ordered either as part of an annual physical or a medical examination for an unrelated condition. An unexplained elevated white blood cell (lymphocyte) count is the most common finding that leads a doctor to consider a CLL diagnosis. Generally, CLL symptoms develop over time. As the disease progresses, a person may experience ...

  • Photo
Read more

Pages

Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.