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Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.

Managing Toxicities of Novel Therapies and Coordinating Care for CLL/SLL and FL Patients

In collaboration with PRIME®
  1.0 AMA PRA Category 1 Credit™/1.0 ACPE credit for pharmacists/1.0 AAPA Category I CME credit for physician assistants/ 1.0 AANP credit for nurse practitioners/1.0 CE contact hour for nurses, case managers and certified health education specialists
 

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Investigational CLL Therapy to Get Priority Review by FDA

Marking another promising advance for the treatment of patients with chronic lymphocytic leukemia, including those with a rare subset of this blood cancer, the U.S. Food and Drug Administration (FDA) has granted priority review for an investigational compound that has shown positive results in a Phase II clinical trial. Venetoclax has shown great potential as a new way of treating CLL patients who have received at least one prior therapy. It also appears to be effective for patients with ...

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Len

My son was rubbing my shoulders and noticed a lump on the side of my neck which freaked him out.  He then told my wife about it and they demanded that I go have it checked. In November 2013, I was diagnosed with chronic lymphocytic leukemia (CLL). I had my second round of treatment this past spring. The first one was rituxan alone and this last time was rituxan along with bendamustine for six months. Our oldest is a freshman in college and likely to be living on his own ...

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New CLL Therapy Showing Promise for AML

LLS-funded researcher Anthony Letai, MD, PhD, talks about how his work led to clinical trials of venetoclax for acute myeloid leukemia (AML) and a priority review by the FDA, and how these developments could ultimately lead to the first new therapy approval for AML in decades. An associate professor in medicine at the Dana-Farber Cancer Institute, Letai has been the recipient of several LLS grants in recent years – supported as a Fellow and Scholar, and most recently, receiving Transla ...

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On Demand Education About MPNs and CLL

LLS has chosen infoScript® as an education tool to provide accurate disease information to patients and their families. Quality education will help make your patient’s appointments more efficient and effective. Our goal is that by using this tool, patients will experience greater quality of life, compliance and adherence, and, ultimately, improved outcomes. How it works: You, the healthcare provider, provides an infoScript sheet to yo ...

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Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.