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Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.

On Demand Education About MPNs and CLL

LLS has chosen infoScript® as an education tool to provide accurate disease information to patients and their families. Quality education will help make your patient’s appointments more efficient and effective. Our goal is that by using this tool, patients will experience greater quality of life, compliance and adherence, and, ultimately, improved outcomes. How it works: You, the healthcare provider, provides an infoScript sheet to yo ...

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Doug Olson

Doug Olson, was diagnosed with chronic lymphocytic leukemia (CLL) in 1996.
For six years he endured what is known as “watch and wait” meaning he was not treated but was monitored frequently for signs that the cancer had advanced.  After 6 years he had to undergo chemotherapy, followed by 5 years of remission. But in 2009 the cancer returned and this time he did not respond to treatment.

In September 2010, Olson became one of the first patients to und ...

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Len

My son was rubbing my shoulders and noticed a lump on the side of my neck which freaked him out.  He then told my wife about it and they demanded that I go have it checked. In November 2013, I was diagnosed with chronic lymphocytic leukemia (CLL). I had my second round of treatment this past spring. The first one was rituxan alone and this last time was rituxan along with bendamustine for six months. Our oldest is a freshman in college and likely to be living on his own ...

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Chronic Lymphocytic Leukemia

  Chronic lymphocytic leukemia (CLL) Is a type of blood cancer that begins in the bone marrow Can progress either slowly or quickly depending on the form it takes Click here to access CLL statistics. What You Should Know CLL is the most common type of leukemia in adults. Hematologists and oncologists are specialists who treat people who have CLL or other types of blood cancer. Some people have CLL that grows slowly while other people have CLL that grows fas ...

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Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.