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Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.

LLS Applauds Approval of New Therapy for CLL Patients

Development of the drug, venetoclax, was supported by LLS funding

Rye Brook, NY – April 12, 2016 – The approval of a new therapy for patients with a high-risk form of chronic lymphocytic leukemia (CLL) is welcome news for patients for whom there have been few other options, The Leukemia & Lymphoma Society (LLS) said today. The U.S. Food and Drug Administration has approved venetoclax (Venclexta ®) to treat patients with a rare subset of CLL in which a piece of chromosome ...

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Patient Ambassador Program - CLL/SLL

B-Educated Get a Healthcare Provider's perspective on living and coping with this disease and disease management strategies. B-Empowered Understand the importance of taking an active role in your care and get tips on working with your health team. B-Connected Hear a patient and caregiver share their experiences with CLL/SLL. Connect with people in your community. Participate in a Q&A session. Find available support and resources.

B-Educated
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Investigational CLL Therapy to Get Priority Review by FDA

Marking another promising advance for the treatment of patients with chronic lymphocytic leukemia, including those with a rare subset of this blood cancer, the U.S. Food and Drug Administration (FDA) has granted priority review for an investigational compound that has shown positive results in a Phase II clinical trial. Venetoclax has shown great potential as a new way of treating CLL patients who have received at least one prior therapy. It also appears to be effective for patients with ...

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New CLL Therapy Showing Promise for AML

LLS-funded researcher Anthony Letai, MD, PhD, talks about how his work led to clinical trials of venetoclax for acute myeloid leukemia (AML) and a priority review by the FDA, and how these developments could ultimately lead to the first new therapy approval for AML in decades. An associate professor in medicine at the Dana-Farber Cancer Institute, Letai has been the recipient of several LLS grants in recent years – supported as a Fellow and Scholar, and most recently, receiving Transla ...

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Doug Olson

Doug Olson, was diagnosed with chronic lymphocytic leukemia (CLL) in 1996.
For six years he endured what is known as “watch and wait” meaning he was not treated but was monitored frequently for signs that the cancer had advanced.  After 6 years he had to undergo chemotherapy, followed by 5 years of remission. But in 2009 the cancer returned and this time he did not respond to treatment.

In September 2010, Olson became one of the first patients to und ...

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Glossary Results

Relapsed CLL

CLL that responded to treatment but then returns.

Refractory CLL

CLL that has not responded to initial treatment. Refractory disease may be disease that is getting worse or staying the same (stable disease).

CD38

An antigen on CLL cells and other cells. The expression of CD38 may be a marker to assist in predicting CLL progression.

Richter transformation

In a small number of patients, there is a progression in their disease. In these patients, CLL takes on the characteristics of an aggressive lymphoma. This change is not a second cancer, but a transformation of the CLL cells.

Small lymphocytic lymphoma (SLL)

A disease with symptoms and treatment that are much like CLL. SLL starts in a lymphocyte in a lymph node. CLL starts in a lymphocyte in the marrow.

Immunoglobulin Heavy Chain Variable Region (IgHv) Gene Status

A marker that can distinguish between CLL subtypes (unmutated IgHv and mutated IgHv). People with CLL with unmutated IgHv gene status may have a more progressive form of the disease.

Zap-70

An abbreviation for the cell protein “zeta-associated protein 70.” A high level of ZAP-70 expression on the cells of patients with B-cell CLL is one of several factors that may predict more progressive disease. Outside of a research laboratory this test is generally not very reliable and should not be used.