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- Generic name:
- Brand name(s), other common name(s):
- Drug type:
- interleukin-6 (IL-6) receptor
- How the drug is given:
- intravenous or subcutaneous use
Indications and Usage
Tocilizumab is approved for the treatment of adults and pediatric patients 2 years of age and older with chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndrome (CRS).
CRS, which is caused by an overactive immune response, has been identified as a potentially severe and life-threatening side effect of CAR T cell therapy for certain cancers.
Side effects needing medical attention
Upper respiratory tract infections, nasopharyngitis (inflammatory attack of the pharynx and nasal cavities), headache, hypertension, increased ALT (alanine aminotransferase [enzyme]) and injection site reactions.
WARNING: RISK OF SERIOUS INFECTIONS
See full prescribing information for complete boxed warning.
- Serious infections leading to hospitalization or death including tuberculosis (TB), bacterial, invasive fungal, viral, and other opportunistic infections have occurred in patients receiving Actemra.
- If a serious infection develops, interrupt Actemra until the infection is controlled.
- Perform test for latent TB; if positive, start treatment for TB prior to starting Actemra.
- Monitor all patients for active TB during treatment, even if initial latent TB test is negative.