Disease Information & Support

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Generic name Ruxolitinib
Pronunciation RUX-soh-LI-ti-nib
Brand name(s), other common name(s) Jakafi®
Drug type  Janus-associated kinase inhibitor
How the drug is given By mouth

Ruxolitinib is FDA approved for treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It is also approved to treat patients with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea.

Side effects needing medical attention: Bruising; dizziness; headache; urinary tract infection; weight gain; flatulence; herpes zoster; low platelet counts; low red blood cell counts; low white blood cell counts. 

Tuberculosis has been reported in patients receiving ruxolitinib for myelofibrosis.

Progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection that can result in death, has been reported with ruxolitinib treatment for myelofibrosis. 

Side effects needing medical attention after stopping this medication: Following interruption or discontinuation of ruxolitinib, symptoms of myelofibrosis generally return to pretreatment levels over a period of approximately 1 week. There have been isolated cases of patients discontinuing Jakafi during acute intervening illnesses, after which the patient's clinical course continued to worsen. It has not been established whether discontinuation of therapy contributed to the clinical course in these patients. When discontinuing therapy for reasons other than thrombocytopenia, gradual tapering of the dose of Jakafi may be considered.
 

 

For information on how to manage the costs of drug therapy, please see Financial Matters and Prescription Drug Coverage, or to speak with an Information Specialist, call (800) 955-4572.

last updated on Monday, December 08, 2014