Disease Information & Support


The Word:


Generic name Chlorambucil
Pronunciation klor-AM-byoo-sil
Brand name(s), other common name(s) Leukeran®
Drug type  DNA-damaging agent
How the drug is given By mouth

Chlorambucil is FDA approved to treat people who have chronic lymphocytic leukemia (CLL), some types of non-Hodgkin lymphoma and advanced Hodgkin lymphoma.

Side effects needing medical attention: Convulsions; cough; fever; chills; sore throat; flank or stomach pain; shortness of breath; rash; sores in the mouth and on the lips; swelling of feet or lower legs; unusual bleeding or bruising; yellowing of eyes and skin; black, tarry stools; blood in urine or stool; hoarseness; lower back or side pain; painful or difficult urination; pinhead-sized red spots on skin; agitation; blisters; hallucinations (seeing, hearing or feeling things that are not there); muscle twitching; peeling or scaling of skin; tremors; trouble walking; weakness (severe) or paralysis; changes in menstrual periods; itching of skin; nausea and vomiting.

Side effects needing medical attention after stopping this medication: Cough; fever; chills; sore throat; shortness of breath; unusual bleeding or bruising; black, tarry stools; blood in urine or stool; pinhead-sized red spots on skin; diarrhea; dizziness; faintness or lightheadedness when getting up from a lying or sitting position; headache; itching, hives or rash; nausea and vomiting; pale skin; painful or difficult urination; sores, ulcers or white spots on lips or in mouth, or painful cold sores or blisters on lips, nose, eyes or genitals; sudden sweating; swollen glands; tightness in chest; troubled breathing after exertion; unusual tiredness or weakness; wheezing; back pain; bone pain; burning, crawling, itching, numbness, prickling, "pins and needles" or tingling feelings; heartburn; lack or loss of strength;loss of appetite; muscle aches; sleeplessness; stomach discomfort, upset or pain, or acid or sour stomach; swelling or inflammation of the mouth; weight loss.


For information on how to manage the costs of drug therapy, please see Financial Matters and Prescription Drug Coverage, or to speak with an Information Specialist, call (800) 955-4572.

last updated on Monday, October 15, 2012