Disease Information & Support


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Cancer treatment, or sometimes the disease itself, can cause peripheral neuropathy (PN) - damage to nerves of the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body. PN is estimated to affect 10 percent to 20 percent of people with cancer. It can be caused by:

  • certain chemotherapeutic agents, such as vincristine (Oncovin®), bortezomib (Velcade®), thalidomide (Thalomid®), lenalidomide (Revlimid®), cytarabine (Cytosar-U®), interferon or methotrexate
  • radiation therapy, although it may take several years for symptoms to appear
  • shingles, a rash that may develop in people with weakened immune systems
  • certain diseases such as myeloma 

Some conditions associated with PN include:

  • diabetes
  • nerve compression caused by vertebral fractures
  • vitamin deficiencies, particularly folate or vitamin B12
  • autoimmune diseases, such as lupus and rheumatoid arthritis
  • hypothyroidism
  • kidney disease

Before you start cancer treatment, let your doctor know if you suffer from any of the above conditions or if you experience any of the following PN symptoms in your arms or legs:

  • numbness
  • tingling
  • burning
  • coldness
  • weakness

Let your doctor know right away if you develop any of the above symptoms as you undergo cancer treatment.

Your doctor may prescribe certain medications and vitamins to help prevent neuropathy during treatment. Talk with your doctor before starting any over-the-counter medications, vitamins or supplements on your own. If you develop PN as a result of chemotherapy, reducing the prescribed drug dose or stopping the drugs completely may help.

Treatment-caused PN may gradually decrease after you complete therapy. Many people recover fully from the disorder over a few months or years. In some cases, the symptoms may persist.

10 Safety Measures for People with PN

  1. Keep all rooms, hallways and stairways well lit.
  2. Install handrails on both sides of stairways.
  3. Remove small area rugs and any other clutter that you could trip over or slip on.
  4. Install grab bars in the shower or hand grips in the tub, and lay down skid-free mats.
  5. Use a thermometer to check that any water you bathe in or use is below 110° F or set your water heater temperature accordingly.
  6. Clean up any spilled water or liquids immediately.
  7. Use nonbreakable dishes.
  8. Use potholders while cooking and rubber gloves when washing dishes.
  9. If you drive, make sure you can fully feel the steering wheel and gas and brake pedals. Also, make sure that you can quickly move your foot from the gas to the brake.
  10. If prescribed, use a cane or walker when moving from one room to the other.
last updated on Wednesday, March 16, 2011

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