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Diagnosing chronic myelomonocytic leukemia (CMML) usually involves a series of repeated tests, including blood and bone marrow tests. Your doctor usually can't confirm a diagnosis of CMML with one lab test result that shows abnormal blood counts. Instead, he or she will monitor you over a period of time with repeat lab tests that show abnormal blood counts. This is done to rule out other diagnoses.

Understanding blood tests and blood counts

Bone marrow testing involves two steps usually done at the same time in a doctor's office or a hospital:

  • a bone marrow aspiration to remove a liquid marrow sample
  • a bone marrow biopsy to remove a small amount of bone filled with marrow

Understanding bone marrow tests

A hematopathologist examines the samples of your blood and marrow to confirm a diagnosis, identify the CMML subtype and look for damage to your chromosomes. A hematopathologist is a specialist who studies blood cell diseases by examining samples of blood and marrow cells and other tissues.

The hematopathologist looks for the following to identify CMML:

  • persistent high levels of monocytes in the blood (greater than 1,000 microliters of blood)
  • less that 20 percent of blast cells in the blood and marrow
  • abnormal changes in any of the cells that develop into red cells, certain white cells or platelets (precursor cells)

Other Diagnostic Tests

Your doctor may order one or more tests such as those below to diagnose CMML:

  • X-rays or computed tomography (CT) scans detect an enlarged spleen or liver.
  • Cytogenetic analysis identifies certain changes in chromosomes and genes and checks for the presence of the Philadelphia (Ph) chromosome or Bcr-Abl gene associated with chronic myeloid leukemia.
  • Blood and urine tests detect high levels of lysozyme, an enzyme found in saliva, tears and some immune cells like monocytes.
  • Additional blood work looks for high levels of proteins called lactate dehydrogenase (LDH) and beta 2-microglobulin, which can indicate tissue damage and increased white-cell production or destruction caused by inflammation or certain types of cancer.

Abnormal Chromosomes

Twenty percent to 40 percent of people with CMML have chromosomes that are abnormal in structure or number (called cytogenetic abnormalities). The hematopathologist examines your blood for any chromosome damage or rearrangements. Your doctor can use this information when designing your treatment plan.

Common cytogenetic abnormalities that affect CMML cells include:

  • A chromosome translocation involving the PDGFR-? and TEL genes. Patients who have the PDGFR-? and TEL gene mutation may respond favorably to treatment with the drug imatinib mesylate (Gleevec®). About 1 percent to 4 percent of CMML patients have this abnormality.
  • Monosomy 7 (chromosome 7 has one copy instead of the normal two) and trisomy 8 (chromosome 8 has three copies), the most common chromosomal abnormalities in CMML patients.
  • A mutation (change) of a specific gene within the gene family known as RAS, such as K-RAS or N-RAS. RAS genes and the proteins they encode regulate cell growth. When a mutation (change) of a RAS gene occurs, cells multiply uncontrollably. This type of mutation occurs in about 35 percent of CMML patients.

Testing for monosomy 7 and the RAS mutation may only be done if you're being treated at a cancer center that's conducting research for CMML treatment.

last updated on Wednesday, March 14, 2012
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